High-Protein Creamy Chicken Mushroom Spinach Bake

ByHannah Peterson

This comforting, one-dish casserole features tender chicken, earthy mushrooms, and nutrient-packed spinach in a rich, creamy cheese sauce, finished with a golden bubbly cheese topping. It’s the perfect high-protein, low-carb dinner that feels indulgent while supporting your health goals. Great for meal prep and family dinners!

Why You’ll Love This Recipe

  • Very high protein from chicken and cheese
  • Low carb and keto-friendly (no pasta or rice)
  • One-pan ease with minimal cleanup
  • Make-ahead and freezer-friendly
  • Packed with veggies for nutrients and volume

Ingredients (Serves 6)

  • 2 lbs (900g) boneless, skinless chicken thighs or breasts, cut into bite-sized pieces
  • 12–16 oz (340–450g) mushrooms, sliced
  • 8–10 oz (225–280g) fresh spinach (or 1 package frozen, thawed and squeezed dry)
  • 8 oz (225g) full-fat cream cheese, softened
  • ½ cup (120ml) heavy cream or full-fat Greek yogurt
  • 1½ cups (150g) shredded mozzarella or Italian blend cheese (divided)
  • ½ cup (50g) grated Parmesan cheese
  • 3–4 cloves garlic, minced
  • 1 tsp Italian seasoning
  • ½ tsp onion powder
  • Salt & black pepper to taste
  • 2 tbsp olive oil or butter (for cooking)
  • Optional: red pepper flakes for heat

Instructions

  1. Preheat oven to 375°F (190°C). Lightly grease a 9×13 glass baking dish.
  2. Heat oil or butter in a large skillet over medium-high heat. Season chicken with salt, pepper, and Italian seasoning. Cook until lightly browned (5–7 minutes). Remove and set aside.
  3. In the same skillet, sauté mushrooms until golden (4–5 minutes). Add garlic and cook 30 seconds until fragrant.
  4. Add spinach and cook until wilted (2–3 minutes). Reduce heat to low.
  5. Stir in cream cheese, heavy cream/Greek yogurt, ½ cup mozzarella, Parmesan, onion powder, and any additional seasoning. Mix until smooth and creamy.
  6. Return chicken to the skillet and stir to coat everything evenly. Transfer the mixture to the prepared baking dish.
  7. Top with remaining mozzarella cheese.
  8. Bake 20–25 minutes until bubbly and cheese is golden brown. Broil for the last 2 minutes if desired for extra browning.
  9. Let rest 5–10 minutes before serving. Garnish with fresh parsley if available.

Prep Time: 15 minutes Bake Time: 25 minutes Total Time: 40 minutes

Nutrition (Per Serving)

  • Calories: ~420
  • Protein: 42g (very high)
  • Total Carbs: 8g
  • Net Carbs: 6g
  • Fat: 26g

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